Genomics Research for Health Equity
Leonardo Mariño-Ramírez, PhD
Division of Intramural Research (DIR)
We use integrative approaches to solve complex and challenging biological problems that are focused on reducing health disparities in underrepresented populations of the United States. Our research focuses on studying both the genetic and environmental contributions to health disparities through a combined analysis of genetic ancestry and electronic health records in large biobank cohorts to discover and map disease genes and their variants.
Socioeconomic deprivation and genetic ancestry interact to modify type 2 diabetes ethnic disparities in the United Kingdom
Type 2 diabetes (T2D) is a complex common disease that disproportionately impacts minority ethnic groups in the United Kingdom (UK). Socioeconomic deprivation (SED) is widely considered as a potential explanation for T2D ethnic disparities in the UK, whereas the effect of genetic ancestry (GA) on such disparities has yet to be studied. We modeled the relationship between SED, GA, and T2D status across the three largest ethnic groups in the UK using multivariable logistic regression. The significant interactions between SED and GA underscore how the effects of environmental risk factors can differ among ancestry groups, suggesting the need for group-specific interventions.